精品久久成人无码片_日韩精品一级黄色视频_91李宗精品72集在线观看_国产成人久久精品激情91_成人做爰高潮片免费漫画视频_免费观看有4138_中文字幕高清无码四页第一页二页三页_亚洲国产精品热久久_亚洲自拍偷拍一区二卡

Klotho is a type-I transmembrane protein that is associated with many functions. A novel ?-glucuronidase, Klotho has been associated with phosphate regulation, organ protection, and aging, among others. Though a single gene, it has three major isoforms: the transmembrane form, a shed soluble form, and a truncated soluble form. The extracellular portion of the protein consists of two glycosyl hydrolase domains referred to as KL1 and KL2. Upon cleavage at the base of the extracellular domain the protein becomes the shed soluble form and is an active form that functions as a hormone. Importantly, Klotho is a receptor and a co-receptor of the phosphate regulation protein FGF-23. While Klotho/FGF-23 homeostasis has primarily been focused on phosphate and vitamin D regulation, continuing research is associating Klotho and FGF-23 with functionality that impacts the heart, bones, blood vessels, and parathyroid gland.

The MicroVue Klotho ***** is a sandwich enzyme immuno***** in a microtiter plate format utilizing a capture monoclonal anti-Klotho antibody specific to the KL2 region coated on the plate and a detection mouse monoclonal anti-Klotho antibody specific to the KL1 region.